Sankar Seramani1, Xuan Vinh To1, Sakthivel Sekar1, Boominathan Ramasamy1, Kishore Bhakoo1, and Kuan Jin Lee1
pCASL is a modified form of CASL where a short train of RF pulses reproduces CASL. pCASL sequence uses
flow driven adiabatic pulses to invert the spin. The labeling efficiency of the
pCASL sequence has a dependency on the velocity of the blood at the labeling. Phase
contrast MRI (PCMRI) was used to measure the velocity of the blood at the
labeling plane and to normalize the CBF value. In this study, we tested pCASL
and PCMRI acquisition on a cohort of control rats vs. hyperglycemic rats and documented
effect of varied labeling efficiency.