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Abstract #3355

To Investigate the Regional Functional Connectivity of DMN Alterations in Hypercapnia

Hou-Ting Yang1, Yi-Jui Liu1, Tzu-Cheng Chao2,3, Wen-Chau Chen4, Teng-Yi Huang5, You-Chia Cheng1, Hsiao-Wen Chung6, Chao-Chun Lin7, Chia-Wei Lin7, and Wu-Chung Shen7

1Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, 2Department of Computer Science and Information Engineering, National Cheng-Kung University, Tainan, Taiwan, 3Institute of Medical Informatics, National Cheng-Kung University, Tainan, Taiwan, 4Graduate Institute of Oncology, National Taiwan University, Taipei, Taiwan, 5Department of Eletrical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan, 6Department of Eletrical Engineering, National Taiwan University, Taipei, Taiwan, 7Department of Radiology, China Medical University Hospital, Taichung, Taiwan

To investigate the relationships among regional activity of DMN in different hypercapnia affect using resting-state functional magnetic resonance imaging (rs-fMRI). 10 healthy males were enrolled in this study. A high-resolution T1WI image and BOLD-EPI were performed by a 3 Tesla MR scanner. The CO2 gas mixture (air, 3%, 5% and 7%) was given at the different hypercanpic for each experiment. Our results show that the functional connectivity of DMN is changed in hypercapnia. FC is slight change in 3% CO2 fractions and gradual reduction as the CO2 fraction increases.

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