Maged Goubran1, Wei Bian1, Brian Boldt1, Mansi Parekh1, David Douglas1, Eugene Wilson1, Lex Mitchell1, Scott Anderson2, Gerry Grant3, Huy Do1, and Michael Zeineh1
1Department of Radiology, Stanford University, Stanford, CA, United States, 2Sports Medicine, Stanford University, Stanford, CA, United States, 3Department of Neurosurgery, Stanford University, Stanford, CA, United States
While many cross sectional DTI
studies have been performed for mild TBI in sports, very few longitudinal
investigations have been performed. We present here a large longitudinal study
assessing white matter integrity in high vs. low contact sports employing whole
brain automated tractography and NODDI. We performed a tract-based analysis at
baseline and longitudinally over 3 years, with both experiments localizing
diffusion changes along the callosum forceps minor, left thalamic radiation and
the superior longitudinal fasciculus. We have also shown that diffusion metrics
correlate with cognition as assessed by the SCAT scores.
