Abstract #3372

G-ratio distribution within the healthy population: the effect of age and gender

Mara Cercignani^1,2, Giovanni Giulietti³, Nick Dowell⁴, Matthew Gabel⁴, Rebecca Broad⁴, P Nigel Leigh⁴, Neil Harrison⁴, and Marco Bozzali³

¹Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, United Kingdom, ²Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy, ³Santa Lucia Foundation, Rome, Italy, ⁴Brighton and Sussex Medical School, Brighton, United Kingdom

This paper investigates the variability of the g-ratio (the ratio of the inner to the outer diameter of a myelinated axon) as a function of age and gender in the healthy population. By combining magnetization transfer and diffusion MRI, the mean g-ratio of 20 white matter tracts was estimated, revealing no gender differences, and a systematic increase with age. Righ vs left hemisphere differences were also detected.

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