Abstract #3406

Age-related alterations in glutamatergic neurotransmission in the anterior and posterior cingulate cortices

Pui Wai Chiu¹, Edward S Hui¹, Queenie Chan², Raja Rizal Azman Raja Aman³, Raymond Chuen Chung Chang⁴, Raymond Chor Kiu Chan⁵, Leung Wing Chu⁶, and Henry Ka Fung Mak¹

¹Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, ²Philips Healthcare, Hong Kong, Hong Kong, Hong Kong, ³Biomedical Imaging, University of Malaya, Kuala Lumpur, Malaysia, ⁴School of Biomedical Sciences, The University of Hong Kong, Hong Kong, Hong Kong, ⁵Neuropsychology and Applied Cognitive Neuroscience Laboratory, Chinese Academy of Sciences, Beijing, China, People's Republic of, ⁶Medicine, Queen Mary Hospital, Hong Kong, Hong Kong

Glutamatergic neurotransmission has an interesting role in aging. The anterior cingulate cortex(ACC) and posterior cingulate cortex(PCC) are focuses for aging research due to their implicated role in cognition. In this study, proton magnetic resonance spectroscopy was used to investigate the changes in glutamatergic neurotransmission during aging by measuring absolute Glx concentration([Glx]_abs) in ACC and PCC in a local Chinese cohort at 3.0T. Significant age-related increases of [Glx]_abs in ACC and PCC might indicate age-related alterations in glutamatergic neurotransmission. Significantly higher overall [Glx]_abs was found in ACC compared with PCC might be attributed to the abundant glutamatergic neurons in the forebrain.

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