Abstract #3418

Normal aging effect on commissure fibers assessed with template-based tractography

Pin-Yu Chen^1,2, Jeng-Min Chiou³, Ya-Fang Yang³, Yu-Ting Chen³, Yu-Ling Chang⁴, Yu-Chun Lo¹, Yu-Jen Chen¹, Yung-Chin Hsu¹, and Wen-Yih I. Tseng^1,2,5

¹Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, ²Department of Life Science, National Taiwan University, Taipei, Taiwan, ³Institute of Statistical Sciences, Academia Sinica, Taipei, Taiwan, ⁴Department of Psychology, National Taiwan University, Taipei, Taiwan, ⁵Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

This study used template-based diffusion spectrum imaging (DSI) tractography to analyze the microstructural integrity of commissure fiber tracts, and applied functional data statistics to analyze the age effect on the tract integrity. The anterior commissure fibers were highly sensitive to the aging effect across the lifespan. The poster commissure fibers became sensitive to the aging effect after 60 years old. In contrast, the age effect of poster commissure fibers appears to occur after age of 60 years old. In conclusion, our study provides evidences for specific degenerative patterns of the commissure fibers tracts in normal ageing which may serve as a useful reference for neurodegenerative diseases.

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