Abstract #3420

White Matter Structural Integrity and Cerebral Arterial Pathology in Normal Aging

Roman Fleysher¹, Michael L Lipton¹, Tatjana Rundek², Richard Lipton³, and Carol Derby⁴

¹Department of Radiology, Albert Einstein College of Medicine, Bronx, NY, United States, ²Departments of Neurology and Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, United States, ³Saul R Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, United States, ⁴Saul R Korey Department of Neurology and Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, United States

Normal aging is associated with changes both in micro-structure of white matter of the brain and in cerebral vasculature. We test the hypothesis that these processes are related by examining the association between fractional anisotropy (a diﬀusion tensor imaging measure of structural integrity) and pulsitility index (a transcranial Doppler ultrasound measure of abnormal arterial flow) in 70 years old and older adults free of stroke and dementia. We identified clusters of significant correlations between the measures, supporting this hypothesis.

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