Abstract #3432

Temporal evolution of diffusion indices in white matter and grey matter of macaque brains with ischemic stroke

Chun-Xia Li¹, Yumei Yan¹, Frank Tong², Doty Kempf¹, Stuart Zola^1,3,4, Leonard Howell^1,3, and Xiaodong Zhang ¹

¹Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, ²Department of Radiology, School of Medicine, Emory University, Atlanta, GA, United States, ³Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, Atlanta, GA, United States, ⁴Atlanta Veterans Affairs Medical Center, Decatur, GA, United States

In the present study, adult macaque monkeys were utilized to characterize the temporal changes of DTI-derived diffusion indices in grey matter (GM) and white matter (WM) after ischemic stroke. Our reults showed that mean diffusivity (MD), radial diffusivity (RD) and axial Diffusivity (AD) decreased significantly in GM and WM immediately post stroke while fractional anisotropy (FA) remained unchanged until 48-hour post stroke. The results demonstrate the sensitivity and robustness of MD, AD and RD to access the ischemic injury of GM and WM during hyperacute stroke, and also reveal the temporal evolutiom of the WM and GM microstructure following stroke onset.

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