Abstract #3435

Intravoxel incoherent motion analysis of renal allograft diffusion with clinical and histopathological correlation in pediatric kidney transplant patients

Clare B Poynton¹, Marsha Lee², Yi Li¹, Zoltan Laszik³, John D Mackenzie¹, Pauline W Worters⁴, and Jesse Courtier¹

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States, ³Department of Pathology, University of California, San Francisco, San Francisco, CA, United States, ⁴GE Healthcare, Menlo Park, CA, United States

This study investigated the use of intravoxel incoherent motion (IVIM) analysis for characterizing diffusion in renal allografts of pediatric transplant recipients. Patients were separated into two groups according to whether or not a renal allograft biopsy resulted in a change in clinical management. Patients requiring a change in management (i.e., increase in immunosuppression) showed statistically significant differences in tissue diffusivity in the region of the biopsy relative to those that did not require any change. These results suggest IVIM analysis may be a useful non-invasive tool for guiding clinical management of pediatric kidney transplant patients.

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