Abstract #3478

Corticospinal Tract Distribution in Motor Cortices of Adult Macaque Brains Revealed by High Angular Resolution Diffusion Imaging Tractography

Yuguang Meng¹ and Xiaodong Zhang^1,2

¹Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, ²Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States

Non-human primates mimick most aspects of humans and are widely used in preclinical or medical studies. Understanding the structural connectivity in non-human primate brains can provide essential reference for translational research. The characterization of the corticospinal tracts plays a crucial role in motor function and has been well studied in human brain. However, it remains not fully understood in non-human primates. In this work, high angular resolution diffusion imaging (HARDI) tractography was utilized to evaluate the corticospinal tracts distribution in sub-regions of motor cortices of adult macaque monkeys, and high similarity to prior ex-vivo results was observed.

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