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Abstract #3484

Super-Resolution Track Density Imaging of 1.4 mm isotropic 7T Whole-Brain Diffusion Magnetic Resonance Images

Ralf L├╝tzkendorf1, Robin M. Heidemann2, Thorsten Feiweier2, Michael Luchtmann3, Sebastian Baecke1, Joern Kaufmann4, Joerg Stadler5, Eike Budinger5, and Johannes Bernarding1

1Biometry and Medical Informatics, University of Magdeburg, Magdeburg, Germany, 2Siemens Healthcare GmbH, Erlangen, Germany, 3Department of Neurosurgery, University of Magdeburg, Magdeburg, Germany, 4Department of Neurology, University of Magdeburg, Magdeburg, Germany, 5Leibniz Institute for Neurobiology, Magdeburg, Germany

Track-density imaging (TDI) is a method to generate super-resolution images from fiber-tracking data (1). Here, we applied this technique to 1.4 mm isotropic 7T whole brain diffusion MR imaging data (dMRI). Besides the well-known large and medium-sized fiber tracts the high resolution of the data allowed visualizing the complex interwoven courses of fiber tracts in the cerebellar-pontine angle as well as showing parts of the trigeminus nerve. Combining TDI with high-resolved diffusion data has a great potential for analyzing the anatomy in vivo of brain structures across different scales as well as the neuronal connectome throughout the whole brain.

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