Measuring diffusion time dependence of pseudo-diffusion using flow compensated pulsed and oscillating gradient sequences
Dan Wu1 and Jiangyang Zhang1,2
1Radiology, Johns Hopkins University School of Medicine, BALTIMORE, MD, United States, 2Radiology, New York University School of Medicine, New Yourk, NY, United States
Intravoxel incoherent motion (IVIM) in the
capillaries reflects capillary geometry and flow velocity, which may be probed
by diffusion MRI measured at varying diffusion times. In this study, we
employed flow-compensated pulsed and oscillating gradient sequences to
investigate the diffusion time dependence of pseudo-diffusion in the mouse
brain with diffusion times ranging from 2.5 ms to 40 ms. We used a simplified
IVIM model to characterize the pseudo-diffusion compartment and flow
compartment based on the relation between capillary segments and diffusion
time/distance. Our results clearly demonstrated diffusion time dependence and
suggested that the pseudo-diffusion fraction increased with increasing diffusion
time.
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