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Abstract #3509

13C MRS in human calf muscles at 7T using a double tuned 4 channel 13C-4 channel 1H transceiver phased array.

Guillaume Donati1, Eulalia Serés Roig1, and Rolf Gruetter1,2

1Laboratory of Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 2Department of Radiology, Universities of Lausanne and Geneva, Lausanne, Geneva, Switzerland

The inherent low sensitivity of 13C MRS makes direct 13C detection challenging. Moreover, the 13C-1H heteronuclear J coupling requires double tuned 13C-1H coils to perform proton decoupling during 13C signal acquisition. High sensitivity can be achieved over a large field-of-view using array coils. We aimed to design and build a 4 channel 13C-4 channel 1H transceiver phased-array coil for 13C-MRS studies in humans at ultra-high field. Electromagnetic performance of the coil was evaluated by FDTD simulations in calf muscles at both frequencies. Finally, 1H-decoupled 13C resonance of Glycogen C1 was successfully detected in volunteer calf muscles at 7T.

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