Sui-Seng Tee1, Valentina Digialleonardo1, Hannah Nikki Aldeborgh1, Julio Alvarez1, Alex Poot1, and Kayvan Rahimi Keshari1
Hyperpolarized
MRI quantifies metabolic fluxes non-invasively. One limitation is the
rapid loss of polarized signal, decaying according to its longitudinal
relaxation (T1) time. We propose the use of a permanent, 1 Tesla spectrometer to
lengthen T1s. We show longer T1 values across different functional groups.
Scalar couplings were also visible and these advantages were translatable to
biologically-relevant settings using perfused bioreactors. As more clinical
trials are performed, it is essential to understand the behavior of HP
molecules at field strengths similar to hospital magnets. Sampling HP
substrates using permanent magnets is simple and cost-effective and will
directly benefit clinical imaging.
