Markus Plaumann1, Thomas Trantzschel1, Joachim Bargon2, Ute Bommerich1, and Johannes Bernarding1
1Department for Biometrics and Medical Informatics, Otto-von-Guericke University Magdeburg, Magdeburg, Germany, 2Institute for Physical and Theoretical Chemistry, University of Bonn, Bonn, Germany
19F containing substrates serve as attractive
reporter molecules for NMR and MRI studies. Applications for in vivo studies are limited by low spin
densities due to restricted concentrations. Using hyperpolarization techniques,
such as Chemically Induced Dynamic nuclear Polarization (CIDNP), this
constrained can be overcome. So far, 19F hyperpolarization generated in D2O, which is a prerequisite for an in vivo application, could only be documented
using laser photo-CIDNP. In this study the successful hyperpolarization of a 19F
nucleus in in 3-fluoro-DL-tyrosine in its free and a complexed form using D2O
as a solvent is presented using a simple LED photo-CIDNP device.
