Esben Søvsø Szocska Hansen1,2, Rasmus Stilling Tougaard1,3, Emmeli Mikkelsen1, Thomas Stokholm Nørlinger1, Lotte Bonde Bertelsen1, Steffen Ringgaard1, Hans Stødkilde-Jørgensen1, and Christoffer Laustsen1
1MR Research Centre, Aarhus University, Aarhus N, Denmark, 2Danish Diabetes Academy, Odense, Denmark, 3Cardiology, Aarhus University Hospital, Aarhus N, Denmark
Cardiac metabolism has gained considerable attention
worldwide lately, both as a diagnostic and prognostication tool, as well as a
novel target for treatment. As human
trials involving hyperpolarized MR in the heart are imminent, we employed a
clinically relevant, large animal model, and sought to evaluate the general
feasibility to detect an imposed shift in metabolic substrate utilization
during metabolic modulation with glucose, insulin and potassium (GIK) infusion.
This study demonstrates that hyperpolarized 13C-pyruvate, in a large
animal, is a feasible method for cardiac studies, and, in combination with GIK intervention;
that it is able to detect imposed metabolic shifts.