Miaomiao Chen1, Xiaolei Zhang1, Yanzi Chen1, Zhiwei Shen1, Wei Hu1, Xilun Ma1, and Renhua Wu1
have developed a CEST MRI method that can measure pH using ioversol, a contrast
agent that is clinically approved for X-ray imaging and has been repurposed for
CEST MRI studies. Using ioversol as a CEST agent, we have measured pH over a range of 6.0
- 7.8 pH units by a novel ratiometric pH MRI method, in a concentration-independent
manner. We also have used this agent and CEST MRI method to measure the
extracellular pH (pHe) within the liver of healthy SD rats.