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Abstract #3699

Magnetic/Upconversion Fluorescent Nanoparticle-Based Dual-Modal Molecular Probes for Imaging of  Lymph Node Metastasis From Pancreatic Cancer in vivo

Kai Cao1, Ruirui Qiao2, and Huimin Wei3

1Radiology, Changhai Hospital, Shanghai, China, People's Republic of, 2Chemistry, Chinese Academy of Sciences, Beijing, China, People's Republic of, 3Clinic and Translational Medicine Center, Changhai Hospital, Shanghai, China, People's Republic of

Construction of the specific pancreatic cancer probe based on upconversion nanoparticles. The probes taking biocompatibility upconversion nanoparticles with unique magnetic properties as a carrier, conjugated with ATF peptide specifically targeting the uPAR. Then, its effect of detection of tumor and lymph node metastasis would be further validated in an orthotopic human pancreatic cancer xenograft model by pathology and dual-modal imaging.

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