Abstract #3708

Arterial spin labeling can detect discreet changes of renal perfusion after oral application of the pain medication diclofenac in healthy subjects

Susanne Tewes¹, Marcel Gutberlet¹, Van Dai Vo Chieu¹, Dagmar Hartung¹, Sebastian Rauhut², Matti Peperhove¹, Frank Wacker¹, Faikah Gueler², and Katja Hueper¹

¹Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Clinic for Nephrology, Hannover Medical School, Hannover, Germany

Diclofenac is a nonsteroidal anti-inflammatory drug that is frequently prescribed to reduce inflammation and pain. It reduces the prostaglandin-synthesis and may consequently have an effect on renal perfusion. We investigated whether arterial spin labeling can detect reduction of renal perfusion after oral and topical application of diclofenac compared to baseline measurements. Ten healthy subjects underwent functional MRI of the kidney. After oral application of diclofenac renal perfusion was reduced compared to baseline measurements (321±13 vs. 345±16 ml/(min*100g), p<0.01). No significant changes were found after topical application. In conclusion, ASL can detect discreet changes of renal perfusion that occur after application of diclofenac.

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