Abstract #3720

DANTE-EPI for CSF Suppression in Cervical Spinal Cord BOLD fMRI at 7T

Alan Charles Seifert^1,2, Hadrien Dyvorne^1,2, Joo-won Kim^1,2, Bei Zhang³, and Junqian Xu^1,2,4

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Department of Radiology, NYU Langone Medical Center, New York, NY, United States, ⁴Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States

A major challenge in spinal cord fMRI is physiological noise due to pulsating CSF, which confounds detection of BOLD signal. In this work, we adapt DANTE to reduce CSF signal contamination in spinal cord BOLD fMRI at 7T. Absolute signal intensity, temporal SNR, and temporal cross-correlation between left and right spinal cord gray matter were measured in DANTE-EPI images at multiple pulse-train lengths and flip angles. Aggressive DANTE preparation suppresses CSF signal, but also significantly reduces spinal cord signal. More conservative DANTE preparation yields an optimal tradeoff between adequate CSF attenuation and preservation of spinal cord signal.

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