Abstract #3725

Echo-Time Optimization in Spin Echo EPI using Hypercapnic Manipulation at 3T

Don Marcial Ragot^1,2 and Jean Chen^1,2

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Roman Research Institute, Toronto, ON, Canada

The optimal echo time (TE) for spin-echo EPI (SE-EPI) BOLD is assumed to be near the tissue T2 (65–100ms at 3 T), but this was never experimentally tested. In this study, we use a hypercapnia paradigm with SE-EPI at different TEs to identify the TE that maximizes BOLD detection at 3 T. Based on the normalized percent change in BOLD signal (∆BOLD%/mmHg), BOLD contrast-to-noise ratio (CNR/mmHg) and temporal signal-to-noise ratio (tSNR), we concluded that the optimal SE-EPI TE may be much shorter than the tissue T2, and the optimal TE at 3 T is near 50ms.

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