Hannah Hare1, Robert Frost1, and Daniel Bulte1,2
1FMRIB, NDCN, University of Oxford, Oxford, United Kingdom, 2Department of Oncology, University of Oxford, Oxford, United Kingdom
1mm isotropic diffusion-weighted images were acquired with readout-segmented EPI at 3T to investigate the effects of partial voluming on the IVIM-derived measures of perfusion and blood volume. The maps produced showed no contrast between white and grey matter, and very high signal from CSF. Both the grey and white matter curves were adequately fitted using a monoexponential model, and only the CSF required a biexponential to fit the data. This suggests that the biexponential signal behaviour typically observed at lower resolutions may arise primarily from the CSF rather than the blood compartment.