Abstract #3750

Chronic RF-coil and electrode implantation approach for long-term EEG-fMRI studies in rodents

Tiina Pirttimäki¹, Artem Shatillo¹, Mikko Kettunen¹, Jaakko Paasonen¹, Raimo Salo¹, Alejandra Sierra Lopez ¹, Kimmo Jokivarsi¹, Ville Leinonen², Simon Quittek³, Asla Pitkänen¹, and Olli Gröhn¹

¹Neurobiology, A.I.Virtanen Institute for Molecular Medicine, University of Eastern Finland, Kuopio, Finland, ²Institute of Clinical Medicine - Neurosurgery, University of Eastern Finland and Neurosurgery of NeuroCenter, Kuopio University Hospital, Kuopio, Finland, ³RAPID Biomedical GmbH Technologiepark Wuerzburg-Rimpar, Rimpar, Germany

Simultaneous EEG-fMRI is routinely used in clinical settings as it provides better temporal and spatial information for example when locating seizure onset zones. In pre-clinical research with small rodents, obtaining simultaneous EEG-fMRI in longitudinal studies has been challenged by a number problems including issues related to magnetic susceptibility artifacts. Here, we demonstrate a modified method for permanent MRI coil and EEG electrode implantation that is suitable for long-term chronic follow-up studies on epileptogenesis with improved data consistency across imaging and video-EEG monitoring sessions.

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