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Abstract #3762

The effect of preterm birth on the thalamocortical development during the neonatal stage: A resting-state fMRI study

Yue Cai1, Xiushuang Wu2, Yuan Shi3, Lizhi Xie4, and Jiahong Gao5

1Biomedical Engineering, Peking University, Beijing, China, People's Republic of, 2Department of Pediatrics, Daping Hospital, Third Military Medical University, Chong Qing, China, People's Republic of, 3Department of Pediatrics, Daping Hospital, Third Military Medical University, Chongqing, China, Chong Qing, China, People's Republic of, 4GE Healthcare, MR Research China, Beijing, Beijing, China, People's Republic of, 5Center for MRI Research and Beijing City Key Lab for Medical Physics and Engineering, Peking University, Beijing, China, People's Republic of

Preterm birth is a leading cause of cognitive impairment in childhood and is associated with cerebral gray and white matter abnormalities. Using the resting-state fMRI imaging analysis, we tested the hypothesis that preterm birth might to some extent affect the thalamo-cortical connections particularly in the thalamo-SM and thalamo-SA projections. Reduced thalamo-SM and increased thalamo-SA connectivity were found in the preterm newborns, and preterm with punctate white matter lesions (PWMLs) exhibited a more sever trend in the thalamo-SA projection.

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