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Abstract #3766

A Preliminary Study of Major Depressive Disorder Using Simultaneous PET/fMRI with Two MID Tasks in a Single Scan

Fuyixue Wang1, Paul Hamilton2, Brian Knutson2, Ian Gotlib2, Matthew Sacchet2, Hershel Mehta2, Christina Schreiner2, Dawn Holley3, Fred Chin3, Bin Shen3, Greg Zaharchuk3, Mehdi Khalighi4, and Gary Glover3

1Department of Biomedical Engineering, Tsinghua University, Beijing, China, People's Republic of, 2Department of Psychology, Stanford University, Stanford, CA, United States, 3Department of Radiology, Stanford University, Stanford, CA, United States, 4Applied Science Lab, GE Healthcare, Menlo Park, CA, United States

The release of dopamine during reward tasks is modulated by major depressive disorder (MDD). In this study of MDD, we used simultaneous PET/fMRI to detect the neurochemical changes of dopamine and neurovascular activity through BOLD contrast during two sequential monetary incentive delay tasks in a single scan. Several modeling methods were proposed and evaluated for dynamic PET data. Six participants with MDD were studied. The results of the group analysis of PET and fMRI show significant effects of dopamine release in ventral striatum bilaterally, close to the nucleus accumbens, and significant BOLD signals in putamen bilaterally during reward tasks.

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