Shruti Agarwal1, Noushin Yahyavi-Firouz-Abadi1, Haris I. Sair1, Raag Airan1, and Jay J. Pillai1
The phenomenon of neurovascular uncoupling (NVU) is a
limitation of clinical fMRI, particularly in presurgical mapping. A previous
study using task-based motor activation (tbfMRI) and breath hold cerebrovascular
reactivity (BH CVR) mapping demonstrated that BH CVR was capable of detecting NVU
in low-grade perirolandic tumors. In this study we demonstrated the
effect of NVU on resting state fMRI (rsfMRI) data within the sensorimotor network through
comparison to both BH CVR and task-based fMRI data.