Abstract #3810

A Brain Resting State network specific T2* Study in neonatal infants

Maryam Abaei¹, Tomoki Arichi^1,2, Anthony Price¹, Eugene P Duff³, Emer Hughes¹, Giulio Ferrazzi¹, Jacques-Donald Tournier ¹, Jonathan O'Muircheartaigh^1,4, Serena Counsell¹, A David Edwards^1,5, Steve M Smith³, Daniel Rueckert⁶, and Joseph V Hajnal^1,5

¹Centre for the Developing Brain, King's College London, London, United Kingdom, ²Department of Bioengineering, Imperial College, London, United Kingdom, ³Department of Clinical Neurosciences, Oxford University, Oxford, United Kingdom, ⁴Institute of Psychiatry, Kings College London, London, United Kingdom, ⁵Division of Imaging Sciences and Biomedical, King's College London, London, United Kingdom, ⁶Biomedical Image Analysis Group, Department of Computing, Imperial College, London, United Kingdom

Previous studies reported that, although the majority of RSNs are present at the time of normal birth, but they appear to mature at different rates with the "higher-order" networks developing later than primary sensory. T₂* in neonates are up to 2 times longer than those typically seen in the mature adult brain and decrease with increasing gestational age at scan. In this study we assessed T₂* for different RSNs and hypothesized that those which mature earlier on structural MRI would have shorter T₂* than networks in cortical regions that develop later in gestation.

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