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Abstract #3826

Task-Driven Functional Connectivity of White Matter in Projection Pathways of the Human Brain

Xi Wu1, Wuzhong Bi1, Stephen K Bailey2, Laurie E Cutting3,4, Jiliu Zhou1, Adam W Anderson4,5,6, John C Gore4,5,6, and Zhaohua Ding5,6,7

1Department of Computer Science, Chengu University of Information Technology, Chengdu, China, People's Republic of, 2Brain Institute, Vanderbilt University, Nashville, TN, United States, 3Kennedy Center, Chengu University of Information Technology, Nashville, TN, United States, 4Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 5Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 6Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 7Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States

Functional MRI has proven to be most effective in detecting neural activity in brain cortices on the basis of hemodynamic responses, but meanwhile has poor sensitivity in detecting neural activity in white matter. In this study, we demonstrate that MRI signals in the projection pathways have significant correlations to the primary motor cortex in finger tapping conditions, and distributions of the correlations bear clear relations with the sidedness of the task. This indicates that MRI signals in white matter may also encode neural activity, which may be detectable with sensitive methods.

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