M. Ethan MacDonald1, Avery J.L. Berman1,2, Erin L. Mazerolle1, Rebecca J. Williams1, and G. Bruce Pike1
1Departments of Radiology & Clinical Neurosciences, University of Calgary, Hotchkiss Brain Institute, Seaman Family MR Research Centre, Foothills Medical Centre, Calgary, AB, Canada, 2Montreal Neurological Institute, Montreal, QC, Canada
In this work we demonstrate the use of BOLD-fMRI
during hyperoxia to obtain perfusion parameters, including CBF, CBV, and MTT. During
BOLD imaging, subjects breathing from a respiratory circuit inhaled air whose
oxygen content was increased from 21% to 70%. The exhaled oxygen concentration was
processed to obtain an arterial input function, and the concentration of bound oxygen
in the venous blood was determined by modeling the BOLD time series. Through
deconvolution modeling we were able to obtain measurements of CBF, venous CBV,
and MTT within expected ranges.
