R2* of liver fat and water compared to proton density fat fraction estimated by 1H MRS
Gavin Hamilton1, Alexandra N Schlein1, Adrija Mamidipalli1, Michael S Middleton1, Rohit Loomba2, and Claude B Sirlin1
1Department of Radiology, University of California, San Diego, San Diego, CA, United States, 2Department of Medicine, University of California, San Diego, San Diego, CA, United States
MRI based methods of estimating hepatic proton density fat
fraction (PDFF) measure only one R2* value, as the R2* of fat and water are
assumed to be identical. MRS can estimate the R2* of both fat and water. Liver
MRS spectra were fitted with constraints derived from those used in MRI, and
water R2* and fat R2*eff (the effective fat R2* that would be
measured by MRI) were compared to PDFF. We found that water R2* was independent
of PDFF, while fat R2*eff was weakly and inversely correlated with
PDFF.
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