MRI Evaluation of Acetaminophen Induced Liver Failure in Mice using T1 Mapping and Stable Gadoxetate Disodium Administration
Christiane Mallett1, Matthew Latourette1, Anna Kopec2, James Luyendyk2, and Erik Shapiro1
1Radiology, Michigan State University, East Lansing, MI, United States, 2Pathobiology & Diagnostic Investigation, Michigan State University, East Lansing, MI, United States
We are developing an
MRI method to measure acetaminophen toxicity in the liver. We obtained T1 maps
using the clinically approved contrast agent gadoxetate disodium (Eovist). The
contrast agent was administered by infusion to maintain a steady liver concentration
throughout the T1 mapping. Mice with acetaminophen toxicity had higher T1 and
heterogeneous gadoxetate disodium uptake compared to healthy controls. This is
a promising method for quantifying drug induced liver damage in vivo.
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