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Abstract #3859

Improving Liver Iron Estimates with a Muscle-based Proton Density Estimate

Eamon K Doyle, MS1, Andrew Powell, MD2,3, and John C Wood, MD, PhD4,5

1Biomedical Engineering, University of Southern California, Sierra Madre, CA, United States, 2Cardiology, Boston Children's Hospital, Boston, MA, United States, 3Pediatrics, Harvard School of Medicine, Boston, MA, United States, 4Cardiology, Children's Hospital of Los Angeles, Los Angeles, CA, United States, 5Biomedical Engineering, University of Southern California, Los Angeles, CA, United States

CPMG-based R2 (1/T2) estimates are traditionally insensitive to tissue iron load. We show that the application of a T1-corrected, skeletal muscle-based proton density constraint increases the sensitivity of R2 for iron quantitation in phantoms and human subjects. This method leads to a fundamentally different R2-LIC (liver iron concentration) calibration curve than has previously been applied to CPMG fit data.

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