Retrospective evaluation of the impact of DWI on PI-RADS scoring of TZ lesions. A blinded radiologist evaluates lesions based on only the DWI sequence and again only on the T2 TSE sequence, in separate occurrences, in patients who underwent targeted biopsy. New PI-RADS scores are given for each of the lesions. The given scores are then correlated with their corresponding Gleason scores. Of the 55 lesions studied, the DWI score downgraded four lesions from a higher T2 score. DWI could play a role in evaluation of TZ lesions, however our data lacked statistical significance.