Emmeli F. R. Mikkelsen1, Thomas S. Nørlinger1, Haiyun Qi1, Ulrich Koellisch2, Rolf F. Schulte3, Michael Pedersen1, Hans Stødkilde-Jørgensen1, and Christoffer Laustsen1
1MRI Research Centre, Aarhus University Hospital, Aarhus N, Denmark, 2Institute of Medical Engineering, Technische Universität München, Munich, Germany, 3GE Global Research, Munich, Germany
Positron Emission Tomography (PET) using carbon-11
acetate has previously been used to reveal the oxidative metabolism in the
kidneys. It has been found that renal carbon-11 acetate turnover measured by
PET was significantly correlated with renal oxygen consumption and tubular
sodium reabsorption measured by an invasive approach. Hyperpolarized MRI is an
alternative method to obtain similar intracellular measures of acetate, and the
aim of this study was therefore to evaluate the rate constants of
hyperpolarized [1-13C]-acetate in rat kidneys. The intrarenal oxygen
level was altered by diuretics, and measures of acetate rate constants were
calculated before and after injection of furosemide.
