Venkatesh Gopalan1, Jadegoud Yaligar1, Navin Michael2, Lee Swee Shean1, Suresh Anand Sadananthan2, Anna Ulyanova1, Bhanu Prakash KN1, and S Sendhil Velan1
1Laboratory of Molecular Imaging, Singapore Bio-Imaging Consortium, BioMedical Sciences, Singapore, Singapore, 2Singapore Instiute for Clinical Sciences, Singapore, Singapore
The goal of this study was to
investigate how dietary fat intake modulates the effect of long term exercise
training on body weight, intrahepatic and intramyocellular lipids (IHL &
IMCL), and effect on insulin sensitivity in an animal model of long-term exercise.
Long term exercise was found to result in significant elevations in IMCL and
IHL under low fat background diet, and significant reductions in IMCL and IHL
under a high fat background diet, compared to sedentary diet-matched controls.
Dietary fat content did not modulate the effect of exercise on insulin