Jadegoud Yaligar1, Sanjay Kumar Verma1, Bhanu Prakash KN1, Tian Xianfeng1, Venkatesh Gopalan1, Swee Shean Lee1, Suresh Anand Sadananthan2, Navin Michael2, Ong Wee Kiat3, Shigeki Sugii 3, and S Sendhil Velan1
1Laboratory of Metabolic Imaging, Singapore Bioimaging Consortium, A*STAR, Singapore, 2Singapore Institute for Clinical Sciences, A*STAR, Singapore, 3Fat Metabolism and Stem Cell Group, Singapore Bioimaging Consortium, A*STAR, Singapore
Obesity and diabetes are
major metabolic disorders associated with dietary intake. Brown adipose tissue (BAT) is major site for adaptive
thermogenesis involving uncoupling protein-1. We performed longitudinal imaging of fat fraction (FF) of interscapular BAT
in control and high fat diet fed rats under thermoneutral and cold exposure conditions on Wistar rats of 7, 11
and 15 weeks. High fat diet
results in increased fat fraction in iBAT. Histology shows increased size of
brown adipocytes which may alter BAT function and
influence thermogenic potential. UCP1 was upregulated in HFD groups.
With cold exposure FF reduced
significantly in control and HFD groups.