Abstract #3929

T2* and T1 assessment of abdominal tissue response to graded hypoxia and hypercapnia using a controlled gas mixing circuit for small animals

Tameshwar Ganesh^1,2, Marvin Estrada³, James Duffin⁴, and Hai-Ling Margaret Cheng^1,2,5,6

¹Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada, ²Physiology & Experimental Medicine, Hospital for Sick Children Research Institute, Toronto, ON, Canada, ³Lab Animal Services, Hospital for Sick Children, Toronto, ON, Canada, ⁴Anesthesia, University of Toronto, Toronto, ON, Canada, ⁵Institute of Biomaterials & Biomedical Engineering, University of Toronto, Toronto, ON, Canada, ⁶The Edward S. Rogers Sr. Department of Electrical & Computer Engineering, University of Toronto, Toronto, ON, Canada

Inspiring gases with altered O2 and CO2 levels is an approach to assess the health of the cerebral vasculature. However, application of this technique in the body is new and less well understood compared to its application in the brain. In this study, we adopt a comprehensive approach to investigate the MR signatures of abdominal tissue response to a wide spectrum of gas challenges. Results in the liver, kidney, and muscle of healthy rats confirmed T2* as a robust marker of blood oxygen saturation but suggested that T1, other than its conventional association to tissue oxygenation, may a marker of blood volume changes.

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