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Abstract #3964

Initial investigation of glucose metabolism in mouse brain using enriched 17O-glucose and dynamic 17O-MRS

Robert Borowiak1,2, Wilfried Reichardt1,2, Dmitry Kurzhunov1, Christian Schuch3, Jochen Leupold1, Thomas Lange1, Marco Reisert1, Axel Krafft1,2, Elmar Fischer1, and Michael Bock1

1University Medical Center Freiburg, Dept. of Radiology - Medical Physics, Freiburg, Germany, 2German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany, 3NUKEM Isotopes Imaging GmbH, Alzenau, Germany

In this work, we demonstrate the feasibility of monitoring glucose uptake in mouse brain using direct 17O-MRS at 9.4 Tesla for the first time. Time-resolved 17O-MRS spectra (temporal resolution: 42 s) are acquired in vivo after injection of D-glucose with 17O-labeled hydroxyl groups. The cerebral rate of glucose metabolism CMRGlc is estimated using a pharmacokinetic model in an anesthetized (1.25% isoflurane) mouse to 0.43 ┬▒ 0.21 ┬Ámol/g/min, which is of the same order of magnitude as reported by 18F-FDG PET.

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