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Abstract #3969

In vivo measurement of metabolic fluxes in mouse dorsal hippocampus using 1H-[13C] NMR spectroscopy at 14.1 Tesla

Antoine Cherix1, Blanca Lizarbe1, Hongxia Lei2,3, and Rolf Gruetter1,2,4

1Laboratory for Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 2Department of Radiology, University of Geneva, Geneva, Switzerland, 3Animal Imaging and Technology Core (AIT), Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 4Department of Radiology, University of Lausanne, Lausanne, Switzerland

1H-[13C] MRS was applied in a mouse dorsal hippocampus to investigate brain metabolism in vivo. The measured fractional enrichments allowed to measure metabolic fluxes using a one compartment model of glucose metabolism. Results were similar to previous study using a 3 times bigger voxel. This study shows that metabolism of the mouse dorsal hippocampus, which is one of the most studied structures of the brain, can be assessed in vivo.

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