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Abstract #3982

In vivo comparison of quadrupole splitting of potassium resonance with dipole-dipole splitting of total creatine resonance in proton MR spectroscopy of human calf muscle

Manuela Barbara Rösler1,2, Nicolas G.R. Behl1, Nadia Benkhedah1, Armin Michael Nagel1,3, and Reiner Umathum1

1Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, 2Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 3Diagnostic and Interventional Radiology, University Medical Center Ulm, Ulm, Germany

Theory predicts that the residual quadrupole interaction of spin-3/2 nuclei with electrical field gradients and the dipole-dipole interaction of coupled spin-1/2 nuclei depend similarly on the angle between the privileged direction and the static magnetic field. In this work, we compare the splitting of the 39K resonance with the splitting of the total creatine resonance in 1H MR spectroscopy in vivo at human calf muscle. We find similar behavior under variation of the angle between B0 and tibia. Therefor we conclude that the potassium ions and creatine are located in an equivalent electromagnetic environments.

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