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Abstract #3984

Dynamic 1H MRS study of water T2* and water concentration contributions to water signal intensity changes in premotor cortex of the norm and in early stage schizophrenia during hemodynamic response to a single stimulus.

Svetlana Sergeevna Batova1, Andrei Valerievich Manzhurtsev2, Maxim Vadimovich Ublinskii2,3, Irina Sergeevna Lebedeva4, Tolibjon Abdullaevich Akhadov3, Petr Evgenevich Menshchikov5, and Natalia Alexandrovna Semenova2,3,5

1Lomonosov Moscow State University, Moscow, Russian Federation, 2Emanuel Institute of Biochemical Physics of Russian Academy of Sciences, Moscow, Russian Federation, 3Radiology, Scientific Research Institute of Children's Emergent Surgery and Trauma, Moscow, Russian Federation, 4Scientific Centre of Mental Health, Moscow, Russian Federation, 5Semenov Institute of Chemical Physics of Russian Academy of Sciences, Moscow, Russian Federation

Using dynamic 1H MRS we have separated T2* and water concentration contributions to changes of MRS detectable water signal in motor cortex after activation by a single short stimulus. We revealed effects of schizophrenia on both parameters in the period of hemodynamic response to stimulation. Decreased changes of T2* and water concentration in schizophrenia might reflect a lower vasodilation caused by a single short stimulus.

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