Abstract #3986

Chronic pain related alterations of regional and interregional glutamate and GABA associations in the human brain

Alexander Gussew¹, Lisa Janetzki², Marianne Cleve¹, Constanze Borys³, and Jürgen r Reichenbach¹

¹Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany, ²Institute of Psychosocial Medicine and Psychotherapy, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany, ³Department of Psychiatry and Psychotherapy, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany

¹H-PRESS and MEGA-PRESS spectroscopy was performed in anterior cingulate cortex (aCC), insula (Ins) and posterior cortex (PC) of 13 matched pairs of chronic low back pain patients and healthy volunteers to quantify regional and interregional Glx and GABA associations in the resting state. Volunteers had negative correlations between GABA in aCC and Glx in Ins and PC (rho < -0.55) as well as positive correlations between Glx in aCC, Ins and PC (rho > 0.65). In contrast, patients had no any comparable metabolic associations, which may be ascribed to disordered functional pathways between brain regions due to the disease.

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