Kimberly L Chan1,2,3, Karim Snoussi2,3, Richard AE Edden2,3, and Peter B Barker2,3
1Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, United States, 2Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, United States, 3F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States
Glutathione (GSH), a redox metabolite, and lactate, a
product of anaerobic energy metabolism, can
both be detected in the human brain using J-difference editing. Editing each will usually co-edit the other
to some degree, as the GSH editing target spin is at 4.56 ppm and the lactate spin
is at 4.1 ppm. In this abstract, we
investigate optimal simultaneous detection of both metabolites, using a
combination of simulations, and phantom and in vivo experiments. We demonstrate a new acquisition protocol
applying 10 ms editing pulses at 4.35 ppm, which successfully edits both GSH
and lactate signals with near maximal efficiency.
