Christoph Juchem1, Hetty Prinsen1, Kevin L Behar1, Robert K Fulbright1, and Douglas L Rothman1
Altered
lipid and protein contents have been detected with MR spectroscopy in acute
multiple sclerosis lesions and speculated to reflect de- and remyelination
processes. To date, however, neither the metabolites involved nor their
pathological relevance have been satisfactorily described. Hofmann et al.
introduced an elegant concept for the separation of biochemicals of varying
metabolic weight based on differences in T1 relaxation behavior (MRM 46, 2001).
Here, we describe T1-encoded MR spectroscopy at 7 Tesla, the extraction of
individual, spectroscopically overlapping lipid/protein signals by
two-dimensional processing and initial applications to the study of the pathological processes associated
to multiple sclerosis tissue injury and repair.
