Abstract #4038

Voxel-Based Analysis of Cerebral Perfusion in Subcortical Ischemic Vascular Dementia and Alzheimer’s Disease Dementia: a Multi-Parametric Multi-TI Arterial-Spin-Labeling Study

Shuang Yang¹, Tianyi Qian², Yao Meng³, Fei Gao¹, Josef Pfeuffer⁴, Guangbin Wang¹, and Bin Zhao¹

¹Shandong Medical Imaging Research Institute, Shandong University, Jinan, China, People's Republic of, ²Siemens Healthcare, MR Collaborations NE Asia, Beijing, China, People's Republic of, ³Shandong provincial Hospital, Shandong University, Jinan, China, People's Republic of, ⁴Siemens Healthcare, Application Development, Erlangen, Germany

This study aims to present the feasibility of multi-TI (mTI)-ASL in distinguishing between AD and SIVD patients in cerebral perfusion. Nineteen SIVD subjects, twelve AD subjects, and ten controls were included in the study. There was no significant difference in CBF between SIVD and HCs, and between SIVD and AD patients. However, significant differences of BAT were detected among all three groups. The mTI-ASL could evaluate the cerebral perfusion of AD and SIVD patients. Compared with CBF, the BAT could better detect perfusion differences and demonstrated better efficiency.

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