XIANGZHU ZENG1, HUISHU YUAN1, YING LIU1, and ZHENG WANG1
Mild cognitive impairment
(MCI) is often considered as an intermediate stage between normal aging and
dementia, as reflected by a higher rate of conversion to clinical Alzheimer’s disease (AD) than in the normal elderly population.
The hippocampal formation is a complex brain region with a primary role in
memory function and vulnerable to neurodegenerative diseases. The aim of this
research is to investigate the atrophy feature of hippocampal subfield and
follow up the changes of hippocampal subfield in about two years by using
automatic segmentation tool in patients with MCI.Our results suggest that compared to ICV, hippocampal subfield could be
a more sensitive to detect cerebral changes of MCI. CA1, CA3 and left entorhinal cortex may be main subfields involved during MCI
stage. Volumes of hippocampal subfield decreased in MCI patients and were
positive correlation with clinical scores. There were also decreases in volumes
of hippocampal subfield in MCI patients with the progress of the disease.