Abstract #4052

Effect of patient motion on the visibility of small veins in T2*w imaging: A simulation experiment with implications for the study of the central-vein-sign (CVS) theory in MS

Nicola Bertolino¹, Michael G Dwyer¹, Paul Polak¹, Samuel Daniel Robinson², Robert Zivadinov^1,3, and Ferdinand Schweser^1,3

¹Buffalo Neuroimaging Analysis Center, Department of Neurology,Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States, ²High Field Magnetic Resonance Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ³MRI Molecular and Translational Research Center, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States

FLAIR* is a fusion of T2-FLAIR and 3D-T2*w images and it is used to assess the central-vein-sign, a recent promising research direction in MRI-based study of Multiple Sclerosis. However in this experiment we show that researchers should be aware that slight patient movement during acquisition can produce blurring effect in 3D-T2*w images. This subtle artifact can mask small vessels even in case which the overall quality of the image is not substantially degraded.

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