Abstract #4060

BA 4p BOLD response profile distinguishes low and high MS morbidity

Adnan A.S. Alahmadi^1,2, Matteo Pardini^1,3, Rebecca S. Samson¹, Egidio D'Angelo^4,5, Karl J. Friston⁶, Ahmed T. Toosy^1,7, and Claudia Angela Michela Gandini Wheeler-Kingshott^1,5

¹NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom, ²Department of Diagnostic Radiology, Faculty of Applied Medical Science, KAU, Jeddah, Saudi Arabia, ³Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy, ⁴Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy, ⁵Brain Connectivity Center, C.Mondino National Neurological Institute, Pavia, Italy, Pavia, Italy, ⁶Wellcome Centre for Imaging Neuroscience, UCL, Institute of Neurology, London, United Kingdom, ⁷NMR Research Unit, Department of Brain Repair and Rehabilitation, Queen Square MS Centre, UCL Institute of Neurology, London, United Kingdom

This study investigates how multiple sclerosis (MS) selectively affects regional BOLD response to variable grip forces (GF). It is known that the anterior and posterior BA4 areas are anatomically and functionally distinguishable – and that in healthy subjects there are linear and non-linear BOLD response components. After modelling BOLD responses with a polynomial expansion of the applied GF during task, we showed that in BA4a MS subjects respond like healthy subjects. BOLD response in BA4p, instead, was altered in MS, with those with greatest disability showing the greatest deviations from the non-linear profile of the healthy response.

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