Abstract #4070

Preliminary Experience Using Magnetic Resonance Fingerprinting in Multiple Sclerosis

Anagha Deshmane¹, Kunio Nakamura², Deepti K Guruprakash², Yun Jiang ¹, Dan Ma³, Jar-Chi Lee ⁴, Elizabeth Fisher ⁵, Richard A. Rudick ⁵, Jeffrey A. Cohen⁶, Mark J. Lowe⁶, Daniel Ontaneda⁶, Mark A. Griswold^1,3, and Vikas Gulani^1,7

¹Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Biomedical Engineering, Cleveland Clinic, Cleveland, OH, United States, ³Radiology, Case Western Reserve University, Cleveland, OH, United States, ⁴Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, United States, ⁵Biogen, Boston, MA, United States, ⁶Mellen Center for Multiple Sclerosis Research and Treatment, Cleveland Clinic, Cleveland, OH, United States, ⁷Radiology, University Hospitals, Cleveland, OH, United States

Magnetic Resonance Fingerprinting (MRF) is used to simultaneously map T₁, T₂, and spin density in the normal appearing white matter and normal appearing grey matter of multiple sclerosis patients and healthy controls. Relaxation parameters measured by MRF are found to be significantly different between MS subjects and healthy controls, to distinguish between relapsing remitting MS and secondary progressive MS in certain brain structures, and to correlate with clinical measures of function and disability.

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