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Abstract #4075

A longitudinal assessment of brain iron using quantitative susceptibility mapping (QSM) in multiple sclerosis (MS) over 2 years

Ferdinand Schweser1,2, Nicola Bertolino1, Michael G Dwyer1, Jesper Hagemeier1, Paul Polak1, Niels P Bergsland1,3, Andreas Deistung4, Bianca Weinstock-Guttman5, J├╝rgen R Reichenbach4,6, and Robert Zivadinov1,2

1Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States, 2MRI Molecular and Translational Research Center, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States, 3MR Research Laboratory, IRCCS Don Gnocchi Foundation ONLUS, Milan, Italy, 4Medical Physics Group, Department of Diagnostic and Interventional Radiology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany, 5Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States, 6Michael Stifel Center for Data-driven and Simulation Science Jena, Friedrich Schiller University Jena, Jena, Germany

Quantitative susceptibility mapping (QSM) is the most sensitive technique currently available to study brain iron in vivo. The technique opens the door to a longitudinal assessment of brain iron, bearing the potential to understand and disentangle factors resulting in the large scatter of reported iron concentrations in later decades of life.

In the present work, we investigated longitudinal changes of brain magnetic susceptibility in a cohort of 40 healthy controls (HCs) and 160 multiple sclerosis (MS) patients over a period of 2 years.

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